Transcriptional activator LAG-3
| Activator_LAG-3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of the csl-notch-mastermind ternary complex bound to dna | |||||||||
| Identifiers | |||||||||
| Symbol | Activator_LAG-3 | ||||||||
| Pfam | PF11498 | ||||||||
| InterPro | IPR021587 | ||||||||
| |||||||||
In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12.[1] Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1.[1]
References[edit]
- ^ a b Petcherski AG, Kimble J (May 2000). "LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway". Nature. 405 (6784): 364–8. Bibcode:2000Natur.405..364P. doi:10.1038/35012645. PMID 10830967. S2CID 4430319.