DCUN1D1

DCUN1D1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TDU, 3TDZ, 4P5O
Identifiers
Aliases	DCUN1D1, DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, defective in cullin neddylation 1 domain containing 1
External IDs	OMIM: 605905 MGI: 2150386 HomoloGene: 10773 GeneCards: DCUN1D1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	182,985,953 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	35,991,594 bp
RNA expression pattern
	Top expressed in
	sperm; ; endothelial cell; ; trabecular bone; ; Achilles tendon; ; middle temporal gyrus; ; Brodmann area 23; ; bone marrow; ; amniotic fluid; ; oral cavity; ; corpus callosum;
	Top expressed in
	spermatid; ; secondary oocyte; ; spermatocyte; ; interventricular septum; ; Paneth cell; ; triceps brachii muscle; ; vastus lateralis muscle; ; temporal muscle; ; yolk sac; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cullin family protein binding; ubiquitin-like protein binding; protein binding; ubiquitin conjugating enzyme binding;
Cellular component	ubiquitin ligase complex; nucleus; cytosol;
Biological process	protein neddylation; positive regulation of ubiquitin-protein transferase activity; post-translational protein modification; positive regulation of protein neddylation;
	Sources:Amigo / QuickGO
Orthologs
	54165
	114893
	ENSG00000043093
	ENSMUSG00000027708
	Q96GG9
	Q9QZ73
	NM_001308101; NM_020640
	NM_001205361; NM_001205362; NM_033623
	NP_001295030; NP_065691
	NP_001192290; NP_001192291; NP_296372
	Wikidata
View/Edit Human	View/Edit Mouse

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.^[5]^[6]^[7]

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.^[8]^[9]^[10]

Interactions[edit]

DCUN1D1 has been shown to interact with:

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000043093 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027708 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics. 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668.
^ Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. Bibcode:2005Natur.435.1257K. doi:10.1038/nature03662. PMID 15988528. S2CID 4328225.
^ "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".
^ Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia. 12 (6): 476–84. doi:10.1593/neo.10202. PMC 2887088. PMID 20563250.
^ Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.
^ Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5): e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
^ ^a ^b ^c ^d ^e Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

Further reading[edit]

Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B (Nov 2004). "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma". The Annals of Thoracic Surgery. 78 (5): 1734–41. doi:10.1016/j.athoracsur.2004.05.056. PMID 15511464.
Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B (Jun 2003). "The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue". Clinical Cancer Research. 9 (6): 2300–6. PMID 12796399.
Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B (May 2004). "Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A". Annals of Surgical Oncology. 11 (5): 530–4. doi:10.1245/ASO.2004.03.014. PMID 15123463. S2CID 7962781.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P (Apr 2005). "Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors". The Journal of Clinical Endocrinology and Metabolism. 90 (4): 2314–20. doi:10.1210/jc.2004-1337. PMID 15623817. S2CID 7907994.
Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B (Dec 2004). "Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas". Surgery. 136 (6): 1122–8. doi:10.1016/j.surg.2004.06.041. PMID 15657565.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000043093 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027708 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10777668-5] Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics. 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668.

[pmid15988528-6] Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. Bibcode:2005Natur.435.1257K. doi:10.1038/nature03662. PMID 15988528. S2CID 4328225.

[entrez-7] "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".

[8] Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia. 12 (6): 476–84. doi:10.1593/neo.10202. PMC 2887088. PMID 20563250.

[9] Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.

[10] Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5): e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.

[pmid18826954-11] Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

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