ALPPL2

ALPG
Identifiers
Aliases	ALPG, GCAP, ALPPL2, alkaline phosphatase, placental like 2, alkaline phosphatase, germ cell, ALPPL
External IDs	OMIM: 171810 MGI: 108009 HomoloGene: 129600 GeneCards: ALPG
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,410,714 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,017,650 bp
RNA expression pattern
	Top expressed in
	placenta; ; right uterine tube; ; lower respiratory tract; ; lung; ; right lung; ; endometrium; ; upper lobe of left lung; ; rectum; ; left uterine tube; ; small intestine;
	Top expressed in
	morula; ; blastocyst; ; secondary oocyte; ; entorhinal cortex; ; spermatid; ; jejunum; ; supraoptic nucleus; ; duodenum; ; primary motor cortex; ; medulla oblongata;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase activity; catalytic activity; hydrolase activity; metal ion binding; alkaline phosphatase activity;
Cellular component	anchored component of membrane; membrane; extracellular region; plasma membrane;
Biological process	metabolism; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	251
	11650
	ENSG00000163286
	ENSMUSG00000026246
	P10696
	P24823
	NM_031313
	NM_007433
	NP_112603
	NP_031459
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.^[5]

Function[edit]

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163286 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026246 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Alkaline phosphatase, placental-like 2".

External links[edit]

Human ALPPL2 genome location and ALPPL2 gene details page in the UCSC Genome Browser.

Further reading[edit]

Shigenari A, Ando A, Baba T, Yamamoto T, Katsuoka Y, Inoko H (November 1998). "Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning". Cancer Research. 58 (22): 5079–82. PMID 9823315.
Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (August 1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5597–601. Bibcode:1986PNAS...83.5597H. doi:10.1073/pnas.83.15.5597. PMC 386335. PMID 3461452.
Jemmerson R, Shah N, Takeya M, Fishman WH (January 1985). "Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells". Cancer Research. 45 (1): 282–7. PMID 2578098.
Shen LP, Liu H, Kan YW, Kam W (June 1988). "5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene". Nucleic Acids Research. 16 (12): 5694. doi:10.1093/nar/16.12.5694. PMC 336801. PMID 3387245.
Lowe ME (February 1992). "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein". The Journal of Cell Biology. 116 (3): 799–807. doi:10.1083/jcb.116.3.799. PMC 2289307. PMID 1730777.
Le Du MH, Stigbrand T, Taussig MJ, Menez A, Stura EA (March 2001). "Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity". The Journal of Biological Chemistry. 276 (12): 9158–65. doi:10.1074/jbc.M009250200. PMID 11124260.
Fisken J, Leonard RC, Shaw G, Bowman A, Roulston JE (January 1989). "Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer". Journal of Clinical Pathology. 42 (1): 40–5. doi:10.1136/jcp.42.1.40. PMC 1141788. PMID 2921344.
Ben-Arie A, Hagay Z, Ben-Hur H, Open M, Dgani R (September 1999). "Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 86 (1): 69–71. doi:10.1016/S0301-2115(99)00054-8. PMID 10471145.
Goldstein DJ, Rogers C, Harris H (October 1982). "A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus". Clinica Chimica Acta; International Journal of Clinical Chemistry. 125 (1): 63–75. doi:10.1016/0009-8981(82)90046-8. PMID 6814793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026246 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Alkaline phosphatase, placental-like 2".

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