DENR (gene)

DENR
Identifiers
Aliases	DENR, DRP, DRP1, SMAP-3, density-regulated protein, density regulated re-initiation and release factor
External IDs	OMIM: 604550 MGI: 1915434 HomoloGene: 6275 GeneCards: DENR
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 122,752,824 bp End 122,771,064 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 124,045,238 bp End 124,066,898 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium visceral pleura parietal pleura endothelial cell Brodmann area 23 palpebral conjunctiva tibia hair follicle biceps brachii oral cavity Top expressed in primitive streak somite yolk sac seminal vesicula abdominal wall maxillary prominence supraoptic nucleus superior cervical ganglion lacrimal gland hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mRNA binding translation initiation factor activity ribosome binding molecular function Cellular component ribosome translation initiation complex cellular component Biological process translational initiation ribosome disassembly protein biosynthesis formation of translation preinitiation complex translation reinitiation IRES-dependent viral translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8562 68184 Ensembl ENSG00000139726 ENSMUSG00000023106 UniProt O43583 Q9CQJ6 RefSeq (mRNA) NM_003677 NM_026603 RefSeq (protein) NP_003668 NP_080879 Location (UCSC) Chr 12: 122.75 – 122.77 Mb Chr 5: 124.05 – 124.07 Mb PubMed search
Wikidata
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Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

Function

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing the HER2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF2 and the initiator Met-tRNA_i^Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008].

See also

• Eukaryotic initiation factors
• Eukaryotic translation

Further reading

• Mazan-Mamczarz K, Gartenhaus RB (2007). "Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1". Cancer Genomics Proteomics. 4 (3): 233–9. PMID 17878526.
• Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA (2017). "Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1". Cell Rep. 20 (3): 521–528. doi:10.1016/j.celrep.2017.06.025. PMC 5551485. PMID 28723557.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.