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Chemical compound
APP-FUBINACA Legal status
N-(1-amino-3-phenyl-1-oxopropan-2-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number PubChem CID UNII CompTox Dashboard (EPA ) Formula C 24 H 21 F N 4 O 2 Molar mass 416.456 g·mol−1 3D model (JSmol )
O=C(N[C@H](C(N)=O)CC1=CC=CC=C1)C2=NN(CC3=CC=C(F)C=C3)C4=C2C=CC=C4
InChI=1S/C24H21FN4O2/c25-18-12-10-17(11-13-18)15-29-21-9-5-4-8-19(21)22(28-29)24(31)27-20(23(26)30)14-16-6-2-1-3-7-16/h1-13,20H,14-15H2,(H2,26,30)(H,27,31)/t20-/m0/s1
Key:TZXBEYFALIFOAG-FQEVSTJZSA-N
APP-FUBINACA is an indazole -based synthetic cannabinoid that has been sold online as a designer drug .[1] Pharmacological testing showed APP-FUBINACA to have only moderate affinity for the CB1 receptor , with a Ki of 708 nM, while its EC50 was not tested.[2] It contains a phenylalanine amino acid residue in its structure.
[3]
Legality [ edit ]
Sweden's public health agency suggested to classify APP-FUBINACA as hazardous substance on March 24, 2015.[4]
See also [ edit ]
References [ edit ]
^ "APP-FUBINACA" . Cayman Chemical. Retrieved 15 July 2015 .
^ WO 2009106982 , Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DL, Kortum SW, Rico JG, Tenbrink RE, Wu KK, "Indazole derivatives", published 3 September 2009, assigned to Pfizer Inc
^ Evelyn, Alex. "HHC (Hexahydrocannabinol)" . Retrieved 19 December 2021 .
^ "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara" . Folkhälsomyndigheten. Retrieved 16 July 2015 .
^ Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, et al. (December 2020). "in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience . 11 (24): 4434–4446. doi :10.1021/acschemneuro.0c00644 . PMID 33253529 . S2CID 227246346 .
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α-Amyrin · β-Amyrin
A-796,260
A-834,735
A-836,339
AM-1172
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AM-1241
AM-2232
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AZ-11713908
Cannabinol
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CBS-0550
CP 55,940
GW-405,833 (L-768,242)
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L-759,633
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PF-03550096
S-444,823
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UR-144
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NAGly (GPR18 )
GPR55
GPR119
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Others: 2-PG (directly potentiates activity of 2-AG at CB1 receptor)
ARN-272 (FAAH-like anandamide transporter inhibitor)